Oct. 11, 2024 | Vince Lara-Cinisomo
Marni Boppart’s trajectory to named professorship at the University of Illinois Urbana-Champaign began as a kid playing in the Pine Barrens of New Jersey.
Boppart, a professor in the Department of Health and Kinesiology in the College of Applied Health Sciences, was named the Saul J. Morse and Anne B. Morgan Professor at an investiture ceremony on Sept. 6.
But long before her illustrious career studying cellular biomechanics and muscle began, Boppart’s interests were taking roots in the woods.
“I would describe myself as a very active kid growing up,” she said at the investiture. “All our recreational time was spent outdoors playing baseball, basketball, kickball, riding my bike and jumping over ramps and doing crazy things that my mom still doesn’t know about. I grew up in in the Pine Barrens of New Jersey, and the woods were our playground. I mention this because it really influenced my decision to pursue my first degree in biology at the University of New Hampshire. This provided the opportunity to continue to explore the great outdoors, hiking, rock climbing, skiing, and even trying my hand at hang gliding—without hurting myself.”
As a biology major, Boppart was required to take a course in immunology and was assigned to write a paper on the effects of exercise on immune function.
“I thought, ‘Well, this was a really odd topic. What would exercise have anything to do with immune cells in the body? If you recall, the 80’s were defined by the fitness craze,” she said. “I think I still have my ThighMaster and Jane Fonda tapes sitting in a closet somewhere. The idea that exercise could be beneficial for health and prevent disease was still relatively new. What started as a simple class assignment grew into a life-long obsession with wanting to understand how exercise or the process of muscle contraction could benefit not only muscle, but all organ systems and whole body health.”
Boppart spent time in the Air Force as an aerospace physiologist, then decided to pursue a Ph.D. in Applied Anatomy and Physiology at Boston University. Working with two “powerhouse investigators” in the field of exercise science—Roger Fielding at BU and Laurie Goodyear at Harvard Medical School—the trio was able to document some of the first observations of molecular changes occurring in human muscle as a result of exercise.
“Like most researchers, I had more questions than answers at the end of my doctoral program: How does exercise, or the process of contraction stimulate molecular changes in muscle, what do these changes really mean for structure and function, and going back to my original interest, what is released by muscle into the circulation that might influence whole body health?,” she said.
For Boppart, those question led to what is now a 30-year career studying muscle.
Using transgenic mice, Boppart and her lab partners were able to determine that the integrin complex not only controlled molecular signaling in muscle, but also contributed to skeletal muscle remodeling and growth in response to exercise.
“But then everything changed in 2013,” she said.
That year, Boppart said, she and her lab mates were the first to report that exercise can result in the accumulation of perivascular stem cells in muscle.
“We found that these cells secrete beneficial factors that not only influence muscle remodeling and growth, but structures outside of muscle as well, including vessels and the brain. And so we started to wonder … could these stem cells be used to treat a disease or condition?”
Boppart’s interest in healthy aging led to a study of whether stem cells could be used to address age-related disabilities, particularly slowing the progression of muscle loss. While she found that stem cells were not effective in slowing the progression of muscle loss or regrowing muscle after disuse, she did find if she isolated nanoparticles (or extracellular vesicles or exosomes) from the stem cells first and then injected them into the aged mice, they could successfully recover muscle growth, which is the first step in preventing disability. That discovery led to new sources of funding, including funding from NASA and private foundations such as the Allen Institute.
Cheryl Hanley-Maxwell, dean of the College of Applied Health Sciences, praised Boppart and her work.
“Being named to an endowed position is a singular honor for faculty members,” Hanley-Maxwell said. “Those who hold named professorships are at the top of their fields, and that is certainly true of our honoree today. When I think of Marni, I think of unwavering integrity, deep intellectual curiosity, unconditional dedication to her students, and absolute passion for her work. And humility.”
The named professorship is endowed by Saul Morse and Anne Morgan. Morse earned two degrees at the University of Illinois, including a law degree and is an alumnus of AHS’s Disability Resources and Educational Services. He retired in 2023 after a 50-year career in law. Morgan is a clinical psychologist who retired after more than 30 years of practice in health psychology.
“I would like to thank our donors, Saul and Anne, for their generous contributions to the University of Illinois and the College of Applied Health Sciences,” Boppart said. “I am deeply honored and humbled by this recognition. And I am humbled because, as I look around the room, I see many experts in the fields of health, aging, and disability. To know that several of you nominated me for this award is a bit overwhelming. Thank you for this opportunity. I will remember tonight always.”
Boppart thanked her mentors, HK Department Head Kim Graber and Professor Jeff Woods, as well as her collaborators and colleagues.
Turning toward her future plans, Boppart is energized about what’s next.
“We would like to use our funding and this professorship to translate our EV therapy to humans. I’m confident we can do this,” she said. “Not only because clinical trials with stem cell-derived EVs are already occurring in the U.S. in places like the Mayo Clinic, but also because I have an amazing interdisciplinary research team to help make it possible.”
Editor’s note:
To reach Vince Lara-Cinisomo, email vinlara@illinois.edu.
